Influenza A in a basic training population: Implications for directly observed therapy

Purpose: To describe our evaluation of basic trainees exposed to influenza A and our experience with mass prophylaxis. Methods: Using a structured int erview, 101 individuals were evaluated for symptoms of influenza A. Nasopha ryngeal wash specimens were obtained from symptomatic troops; amantadine pr ophylaxis was prescribed for all, Diagnosis was confirmed using a rapid inf luenza assay or shell vial culture. After completing prophylaxis, the group was reevaluated to determine medication compliance and perceived side effe cts. Results: At baseline, 80 trainees reported symptoms. Three additional cases of influenza were identified, two using the rapid assay. Reported com pliance with amantadine prophylaxis was 46.5%, Conclusions: Nonspecific com plaints that could be consistent with viral infection were numerous in this basic trainee cohort. The rapid assay allowed us to expediently identify a dditional patients, who were then removed from the cohort to limit further transmission. Compliance with prophylaxis was poor; thus, directly observed therapy is recommended.