Propagation of cell death during myocardial reperfusion

Authors
Garcia-Dorado, D Ruiz-Meana, M
Citation
D. Garcia-dorado et M. Ruiz-meana, Propagation of cell death during myocardial reperfusion, NEWS PHYSL, 15, 2000, pp. 326-330
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
15
Year of publication
2000
Pages
326 - 330
Database
ISI
SICI code
0886-1714(200012)15:<326:POCDDM>2.0.ZU;2-J
Abstract
During myocardial reperfusion, increased cytosolic Ca2+ concentration may c ause hypercontracture and cell death. Hypercontracture can propagate to adj acent cells by a gap junction-dependent mechanism. This propagation explain s infarct geometry and increases the final extent of necrosis. Its preventi on may represent a new therapeutic strategy for treating patients with myoc ardial infarction.