CHEMISTRY OF THE CYTOTOXIC PRINCIPLES OF THE MARINE FUNGUS LIGNINCOLA-LAEVIS

Authors
ABRAHAM SP HOANG TD ALAM M JONES EBG
Citation
Sp. Abraham et al., CHEMISTRY OF THE CYTOTOXIC PRINCIPLES OF THE MARINE FUNGUS LIGNINCOLA-LAEVIS, Pure and applied chemistry, 66(10-11), 1994, pp. 2391-2394
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Pure and applied chemistry → ACNP
ISSN journal
00334545
Volume
66
Issue
10-11
Year of publication
1994
Pages
2391 - 2394
Database
ISI
SICI code
0033-4545(1994)66:10-11<2391:COTCPO>2.0.ZU;2-T
Abstract
A methylene chloride: methanol (2:1v/v) extract of the marine fungus L ignincol laevis was found to inhibit the growth of mouse murine leukem ia cells (L 1210). Large scale culturing followed by fractionation of the extract on silica gel has resulted in the isolation of a cytotoxic 1 along with 7-hydroxyergosterol 2 and a ceramide 3. Structures of th e isolated compounds were established with the help of two-dimensional NMR spectroscopy.