The significance of thymidine phosphorylase expression in colorectal cancer

Authors
Katsumata, K Sumi, T Yamashita, S Takahashi, S Mori, M Baba, T Murohashi, T Nagashima, K Ashizawa, T Yamamoto, K Koyanagi, Y Katoh, K
Citation
K. Katsumata et al., The significance of thymidine phosphorylase expression in colorectal cancer, ONCOL REP, 8(1), 2001, pp. 127-130
Citations number
17
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021335X → ACNP
Volume
8
Issue
1
Year of publication
2001
Pages
127 - 130
Database
ISI
SICI code
1021-335X(200101/02)8:1<127:TSOTPE>2.0.ZU;2-B
Abstract
We measured thymidine phosphorylase activity in colorectal cancer tissue an d conducted immunostaining to investigate enzyme expression in the tumor ti ssue. The results showed a correlation between staining ratio of thymidine phosphorylase and cancer progression as well as a correlation between enzym e activity and staining ratios of cancer cells and stromal cells. Since enz yme activity levels can be judged by staining ratios, this method may be us eful for assessing cancer malignancy.