Citation
Sf. Brady et al., Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus, ORG LETT, 2(25), 2000, pp. 4047-4049
Citations number
18
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060
→ ACNP
Volume
2
Issue
25
Year of publication
2000
Pages
4047 - 4049
Database
ISI
SICI code
1523-7060(200012)2:25<4047:CAABNB>2.0.ZU;2-I
Abstract
The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial a
ssay used to identify compounds that damage DNA or inhibit DNA synthesis en
d thereby identify potential natural product anticancer agents. Bisanthraqu
inones based on a 1,3,6,8-tetrahydroxyanthraquinone-type carbon skeleton we
re isolated from an endophytic fungus and characterized by NMR and X-ray cr
ystallography. Cytoskyrin A (1) is highly active in the biochemical inducti
on assay, while the closely related cytoskyrin B (2) has no detectable acti
vity in this assay.