ADVANCES IN AIDS CHEMOTHERAPY - THE ASYMMETRIC-SYNTHESIS OF CRIXIVAN(R)

Authors
REIDER PJ
Citation
Pj. Reider, ADVANCES IN AIDS CHEMOTHERAPY - THE ASYMMETRIC-SYNTHESIS OF CRIXIVAN(R), Chimia, 51(6), 1997, pp. 306-308
Citations number
5
Categorie Soggetti
Chemistry
Journal title
Chimia → ACNP
ISSN journal
00094293
Volume
51
Issue
6
Year of publication
1997
Pages
306 - 308
Database
ISI
SICI code
0009-4293(1997)51:6<306:AIAC-T>2.0.ZU;2-5
Abstract
The discovery and development of an efficient, practical asymmetric sy nthesis of the HIV Protease inhibitor CRIXIVAN(R) is described. Partic ular emphasis is placed on the selective installation of each of the f ive stereogenic centers as well as design strategies associated with t he preparation of a complex pharmaceutical agent needed in multiton qu antities.