Synthesis of substituted N-(4-piperidyl)-N-(3-pyridyl)amides with antiarrhythmic activity. Note 1

The synthesis of analogues of N,2-diphenyl-N-(4-piperidyl)acetamide endowed with antiarrhythmic activity is reported. Benzoyl, cinnamoyl acetyl and pr opionyl groups replace the phenacyl group as N-acyl substituent, while pyri dine replaces benzene as aromatic ring bound to the amide nitrogen. The tit le compounds were evaluated for antiarrhythmic activity on experimenthal ar rhythmias induced by aconitine in rats. The presence of a n-propyl chain an d an unsubstituted cinnamoyl moiety (1j) gives the highest protection again st aconitine induced extrasystoles while the best efficacy against lethal e ffects is due to the presence of a n-propyl chain and an acetyl moiety (1m) .