Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides

This study describes the antinociceptive activity of some N-aryl-glutaramic acids and N-aryl-glutarimides in writhing and formalin tests, two classica l models of pain in mice. These compounds show high activity, being more ac tive than acetyl salycilic acid, acetaminophen and indomethacin, used as st andard drugs for comparison. The introduction of different substituent grou ps in the aromatic ring caused a significant change in activity. The result s obtained here are promising from a pharmacological point of view, since t hese simple compounds might be used as models to obtain new and potent anal gesic drugs.