Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha

The aqueous and ethanol extracts from the leaves of Gochnatia polymorpha an d further fractions obtained from the latter extract using solvents with in creasing polarity, including its aqueous residue and the amino acid, 4-hydr oxy-N-methyl-proline were investigated by carrageenin-induced pedal oedema formation. It was shown that the aqueous and ethanol extracts and the ethyl acetate fraction demonstrated significant antiinflammatory activity. The c hemical investigation of the latter fraction revealed the presence of caffe ic acid, chlorogenic acid, 3-O-methylquercetin, hyperosid and rutin, The am ino acid 4-hydroxy-N-methyl-proline, a nonprotein amino acid that has not b een reported before in the Asteraceae was isolated as a major compound and identified by spectroscopic methods. Copyright (C) 2000 John Whey & Sons, L td.