CATALYTIC ENANTIOSELECTIVE ADDITION OF HYDROGEN-CYANIDE TO BENZALDEHYDE AND P-METHOXYBENZALDEHYDE USING CYCLO-HIS-(ALPHA-ME)PHE AS CATALYST

Authors
HULST R BROXTERMAN QB KAMPHUIS J FORMAGGIO F CRISMA M TONIOLO C KELLOGG RM
Citation
R. Hulst et al., CATALYTIC ENANTIOSELECTIVE ADDITION OF HYDROGEN-CYANIDE TO BENZALDEHYDE AND P-METHOXYBENZALDEHYDE USING CYCLO-HIS-(ALPHA-ME)PHE AS CATALYST, Tetrahedron : asymmetry, 8(12), 1997, pp. 1987-1999
Citations number
58
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
12
Year of publication
1997
Pages
1987 - 1999
Database
ISI
SICI code
0957-4166(1997)8:12<1987:CEAOHT>2.0.ZU;2-T
Abstract
Two cyclo-dipeptides based on His and the unnatural (alpha Me)Phe have been examined as catalysts in the enantioselective addition of hydrog en cyanide to benzaldehyde and p-methoxy-benzaldehyde. The synthesis, catalytic activity and NMR study towards the mechanism of this reactio n are presented. (C) 1997 Elsevier Science Ltd.