R. Hulst et al., CATALYTIC ENANTIOSELECTIVE ADDITION OF HYDROGEN-CYANIDE TO BENZALDEHYDE AND P-METHOXYBENZALDEHYDE USING CYCLO-HIS-(ALPHA-ME)PHE AS CATALYST, Tetrahedron : asymmetry, 8(12), 1997, pp. 1987-1999
Two cyclo-dipeptides based on His and the unnatural (alpha Me)Phe have
been examined as catalysts in the enantioselective addition of hydrog
en cyanide to benzaldehyde and p-methoxy-benzaldehyde. The synthesis,
catalytic activity and NMR study towards the mechanism of this reactio
n are presented. (C) 1997 Elsevier Science Ltd.