Hyperhomocysteinaemia: Physiophatology and medical implications.

Homocysteine is an intermediate aminoacid result of the conversion of methi onine to cysteine. Homocystinuria or the hyperhomocysteinaemia are the most frequently related disorders of this aminoacid, being the former an. autos omic recessive alteration, whereas the latter is conditioned by multiple fa ctors, being the most important the genetic and nutritional factors. In the last years this alteration has regained special interest because of its increasing role in the thrombotic pathologies and the identification th at hyperhomocysteinaemia represents art independent risk factor for the acc elerated atherogenesis of multiple diseases. In this review physiopathologi cal aspects and clinical implications of hyperhomocysteinaemia are mentione d as well as its diagnoses and treatment.