Approaches to prediction of the risk to develop gastropathy due to non-steroid antiinflammatory drugs

Aim. Examination of gastric secretion in rheumatoid arthritis (RA) patients and its response to sodium diclophenak and indomethacine. Materials and methods. 46 RA patients entered the study. All of them have b een long on nonsteroid antiinflammatory drugs (NAID). Two groups of patient s were analysed: group 1 - free of NAID gastropathy, group 2 - with NAID ga stropathy. pH was followed by Gastroscan system. Results. The analysis of 24-h pH-grams in both groups when NAID were not ta ken showed that in NAID gastropathy acid-forming gastric function is not af fected while the alkalizing function markedly declines. Indomethacine is mo re aggressive to upper gastrointestinal tract mucosa than sodium diclophena k. Conclusion. Dynamic intragastric pH-metry can prognosticate the risk of NAI D gastropathy.