Changes in the levels of acute phase proteins in viral hepatic lesions

Aim. To investigate changes in the levels of acute phase proteins (APP) in the serum of patients,vith acute and chronic viral hepatitis of various eti ology. Material and methods. APP (prealbumin albumin, transferrin, haptoglobin) we re measured by automatic kinetic analyzer JCS II TM (Beckman) in 92 patient s with acute and 61 patients with chronic viral hepatitis. Synthesis of alb umin, prealbumin was depressed of haptoglobin increased in patients with ac ute viral hepatitis irrespective of etiology at the height of intoxication. In chronic viral diseases APP content depended on the disease etiology. In chronic hepatitis C, B+C and D albumin, haptoglobin and transferrin were l ow in clinical exacerbation while in patients with chronic hepatitis B a fa ll in albumin, prealbumin and transferrin is accompanied with high haptoglo bin. Conclusion. A complicated multidirectional changes in APP in patients with acute or chronic hepatitis serve, on the one hand an integral diagnostic in dication of hepatic function in conditions of systemic endotoxemia. On the other hand endotoxemia is caused by lipopolysaccharides of gram-negative ba cterin entering blood flow in great amounts in morphofunctional hepatic dis orders caused by viral hepatitis of different etiology.