Redergin treatment of hypertensive menopausal women

Aim. To assess a hypotensive effect of redergin (dihydroergotoxin) - agonis t of dopaminergic receptors - in monotherapy (4.5-6 mg/day) and in combinat ion with enalapril and amlodipin (10 mg/day). Material and methods. Redergin in monotherapy or combined therapy was given to 106 hypertensive women in pre- or postmenopause and 24 hypertensive wom en of reproductive reproductive age. Antihypertensive effect was assessed b y changes in arterial pressure, frequency and severity of hypertensive hype rtensive crises, diuresis, clinical symptoms of menopausal syndrome. Results. A significant fail in arterial pressure, intensive diuresis, less frequent or absent hypertensive crises, relief of menopausal symptoms were observed on day 10-14 of redergin monotherapy of menopausal patients with m ild hypertension and in combined treatment of menopausal women with moderat e and severe hypertension. Conclusion. Antihypertensive and diuretic effect of redergin confirm a path ogenetic role of deficient dopaminergic activity in development of menopaus al hypertension.