Early electron microscopic observations of synaptic structures in the cerebral cortex: a view of the contributions made by George Gray (1924-1999)

The first clear account of synaptic structures in the cerebral cortex was p rovided by George Gray in 1959. Here we look at the background to this stud y, which established some clear structural distinctions between synaptic ty pes, and enquire about the extent to which these distinctions can be relate d to contemporary knowledge of synaptic organization.