This case report describes the successful surgical treatment of a canine co
mpound odontoma using guided bone regeneration. A five-month-old male Labra
dor cross dog was diagnosed with a compound mandibular odontoma. After surg
ical removal of the denticles and curettage of the lining of the bony cavit
y, a combination of autogenous cortico-cancellous bone graft and a bovine-d
erived, purified bone mineral matrix was packed into the defect. A resorbab
le collagen membrane was then secured over the graft and the gingival tissu
es sutured. Radiographs taken four months later revealed advanced graft inc
orporation and bony healing of the mandibular defect. A second surgery was
necessary to remove redundant gingival tissue dorsal to the lesion. Eight m
onths after the first operation, radiographs revealed complete bony union a
nd remodeling of the mandibular ramus. It is concluded that grafting of com
pound mandibular odontomas can be a viable surgical alternative to other mo
re aggressive procedures such as a partial mandibulectomy in the dog.