Common experience teaches that the pressure required to inflate a balloon i
s noticeably reduced by prestretching it several times prior to its primary
inflation. This preconditioning phenomenon is known as stress-softening an
d often is called the Mullins effect. A theory of stress-softening in incom
pressible isotropic materials is applied to study this effect in an equibia
xial extension for which some general results are presented. It is shown, f
or example,, that effects of stress-softening in a simple uniaxial compress
ion can be adduced from those demonstrated for equibiaxial extension under
plane stress. The general equibiaxial results ate applied to study the Mull
ins effect in the inflation of a spherical membrane. The stress-softening p
henomenon in cyclic inflation and deflation of the balloon is investigated
for Mooney-Rivlin and biotissue parent material models. Tt is shown analyti
cally that the effect of preconditioning in uniaxial extension is to signif
icantly reduce the pressure required to first inflate a balloon to an equiv
alent strain intensity. This result characterizes the familiar softening ph
enomenon associated with balloon inflation.