This manuscript addresses the pathogenesis of allergic rhinitis, use of nas
al provocation as a method to assess inflammatory mediators and the role of
cytokines, and topical glucocorticosteroids. Immunologic changes of allerg
en immunotherapy, pharmacotherapy with a focus on non-sedating, and topical
antihistamines are discussed. The antiinflammatory potential of fexofenadi
ne, azelastine, and newer therapeutic modalities with anti-IgE are addresse
d.