Chronic systemic (hepatosplenic) candidiasis (CSC) is a syndrome of invasiv
e candidiasis characterized by fever without localizing signs or symptoms.
It occurs predominantly in patients with acute leukemia, after prolonged se
vere neutropenia. We report a young woman who underwent extensive chemother
apy for granulocytic sarcoma of the ovary; CSC then developed in this patie
nt. She was successfully treated with fluconazole and liposomal amphoterici
n B. Clinical presentation, diagnostic problems, and the current successful
treatment with fluconazole and liposomal amphotericin B are discussed.