Chronic systemic (hepatosplenic) candidiasis in a patient with granulocytic sarcoma

Chronic systemic (hepatosplenic) candidiasis (CSC) is a syndrome of invasiv e candidiasis characterized by fever without localizing signs or symptoms. It occurs predominantly in patients with acute leukemia, after prolonged se vere neutropenia. We report a young woman who underwent extensive chemother apy for granulocytic sarcoma of the ovary; CSC then developed in this patie nt. She was successfully treated with fluconazole and liposomal amphoterici n B. Clinical presentation, diagnostic problems, and the current successful treatment with fluconazole and liposomal amphotericin B are discussed.