The aim of our study was to explore the possible relationship between patie
nt satisfaction with antiemetic treatment and quality of life (QoL). The st
udy sample consisted of 136 chemotherapy-naive patients with breast cancer,
with Karnofsky index 90% to 100%, scheduled to receive their first cycle o
f, mainly adjuvant, 5-fluorouracil/doxorubicin/cyclophosphamide chemotherap
y. Two antiemetic regimens were used for the prevention of acute emesis. No
antiemetic prophylaxis was given for delayed emesis. QoL was assessed usin
g the Rotterdam Symptom Checklist (RSCL). The RSCL was completed before che
motherapy (day 1) and on day 5. Statement of satisfaction was given on day
5. The change in RSCL scores between day 5 and day 1 was calculated and com
pared in three subgroups of patients: those very satisfied (n = 55), satisf
ied (n = 65), and unsatisfied with antiemetic treatment (n = 16). Patient s
tatement of satisfaction was related to psychological distress (p = 0.002),
physical symptom distress (p = 0.002), and activity level (p, = 0.002). It
was also related to the control of nausea (p < 0.01) and vomiting (p < 0.0
001). We suggest that patient statement of satisfaction with antiemetic tre
atment could be an outcome measure for response assessment in antiemetic tr
ials.