Ss. Sun et al., Tissue polypeptide-specific antigen and carcinoembryonic antigen for earlyprediction of recurrence in lung adenocarcinoma, AM J CL ONC, 23(6), 2000, pp. 605-608
Citations number
21
Categorie Soggetti
Oncology
Journal title
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Fifty patients with lung adenocarcinoma, including 20 cases with recurrence
and 30 cases without recurrence 1 year after operation, were enrolled in t
his study. The serial serum levels of tissue polypeptide-specific antigen (
TPS) and carcinoembryonic antigen (CEA) were measured before operation and
at 1 week, and at 1, 3, 6, 9, and 12 months after operation for early detec
tion of recurrence. The results revealed that: 1) mean serum values of TPS
were significantly higher at 1, 3, 6, 9, and 12 months after operation in 2
0 patients with recurrent adenocarcinoma, when compared with 30 patients wi
thout recurrent adenocarcinoma; 2) mean serum values of CEA were significan
tly higher at 9 months and 12 months after operation in 20 patients with re
current adenocarcinoma, when compared with 30 patients without recurrent ad
enocarcinoma. We conclude that TPS is a better marker than CEA for early pr
ediction of adenocarcinoma recurrence in lung within 1 year after operation
. However, a longer follow-up study should be encouraged.