Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs transferrin receptor concentration
Fh. Wians et al., Discriminating between iron deficiency anemia and anemia of chronic disease using traditional indices of iron status vs transferrin receptor concentration, AM J CLIN P, 115(1), 2001, pp. 112-118
Citations number
38
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
We compared the ability of soluble serum transferrin receptor (TfR) concent
ration, quantified using the R&D Systems (Minneapolis, MN) enzyme-linked im
munosorbent TfR assay, with other more traditional indicators of iron statu
s (total iron binding capacity [TIBC], mean corpuscular volume [MCV] percen
t transferrin saturation [%TS] RBC distribution width (RDW] and serum iron
concentration [SIC])for discriminating between patients with iron deficienc
y anemia (IDA) or anemia of chronic disease (ACD). The TfR concentration wa
s determined in 72 serum samples selected from men and nonpregnant women cl
assified biochemically on the basis of ferritin concentration as having IDA
(n = 41) or ACD (n = 31). By using receiver operating characteristic curve
analysis, the diagnostic accuracy of the various indicators of iron status
that we evaluated for discriminating between IDA and ACD decreased in the
following order TIBC > TfR > MCV > (%TS = RDW) > SIG. There was no signific
ant difference between the diagnostic accuracy of TIBC and TfR. Thus, the r
outine measurement of TfR offers no advantage over TIBC for discriminating
between people with biochemically defined IDA or ACD.