EBV-associated perianal Hodgkin's disease in an HIV-positive individual

Citation
M. Sapp et al., EBV-associated perianal Hodgkin's disease in an HIV-positive individual, AM J HEMAT, 66(1), 2001, pp. 42-45
Citations number
11
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF HEMATOLOGY
ISSN journal
03618609 → ACNP
Volume
66
Issue
1
Year of publication
2001
Pages
42 - 45
Database
ISI
SICI code
0361-8609(200101)66:1<42:EPHDIA>2.0.ZU;2-5
Abstract
Hodgkin's disease (HD) has a higher incidence in HIV-positive individuals. It tends to occur at extranodal sites, frequently exhibits an unfavorable h istological type with large numbers of neoplastic cells, and almost invaria bly harbors Epstein-Barr Virus (EBV). We describe a case of a 33-year-old H IV-positive man who presented with anal pain from a 4-cm mass in the anorec tal canal. He had no a symptoms or peripheral lymphadenopathy. A chest X-ra y was within normal limits. A biopsy showed an ulcerated mass composed of a mixed infiltrate of lymphocytes, plasma cells, eosinophils, and Reed-Stern berg (RS) cells positive for CD15 and strongly positive for CD30. They were negative for CD45 and CD20. Numerous RS cells and lymphocytes were positiv e for EBV RNA using the EBER-1 probe. This highly unusual presentation of H o may reflect the greater incidence of anorectal lymphoma and of extranodal HD in the HIV-positive population. (C) 2001 Wiley-Liss, Inc.