Unilateral glaucoma in Sotos syndrome (cerebral gigantism)

PURPOSE: To report a patient with unilateral glaucoma associated with Sotos syndrome. Sotos syndrome (cerebral gigantism) is a disorder of growth and development with characteristic facial changes and normal endocrine functio n. Ocular manifestations may also include megalocornea, iris hypoplasia, ca taracts, megalophthalmos, strabismus, nystagmus, and retinal dystrophy, METHODS: Case report. A 50 year-old man with the clinical features of Sotos syndrome presented with complaints of decreased vision in the left eye, RESULTS: Ophthalmologic examination revealed bilateral megalocornea, megalo phthalmos, iris hypoplasia and transillumination defects, cataracts, and un ilateral glaucoma. Intraocular pressure was lowered, and visual field loss was stabilized with topical medications. CONCLUSION: Sotos syndrome patients should be examined routinely to allow f or early detection and treatment of potential ocular problems, including gl aucoma. (C) 2000 by Elsevier Science Inc. All rights reserved.