Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae

Authors
Depardieu, F Courvalin, P
Citation
F. Depardieu et P. Courvalin, Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae, ANTIM AG CH, 45(1), 2001, pp. 319-323
Citations number
31
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
1
Year of publication
2001
Pages
319 - 323
Database
ISI
SICI code
0066-4804(200101)45:1<319:MI2RRF>2.0.ZU;2-4
Abstract
Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-member ed macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.