In vitro susceptibility testing methods for caspofungin against Aspergillus and Fusarium isolates

Authors
Arikan, S Lozano-Chiu, M Paetznick, V Rex, JH
Citation
S. Arikan et al., In vitro susceptibility testing methods for caspofungin against Aspergillus and Fusarium isolates, ANTIM AG CH, 45(1), 2001, pp. 327-330
Citations number
26
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
1
Year of publication
2001
Pages
327 - 330
Database
ISI
SICI code
0066-4804(200101)45:1<327:IVSTMF>2.0.ZU;2-F
Abstract
We investigated the relevance of prominent reduction in turbidity macroscop ically (MIC) and formation of aberrant hyphal tips microscopically (minimum effective concentration; MEC) in measuring the in vitro activity of caspof ungin against Aspergillus and Fusarium. Caspofungin generated low MICs and MECs against Aspergillus, but not for Fusarium. While MICs increased incons istently when the incubation time was prolonged, MEC appeared as a stable a nd potentially relevant endpoint in testing in vitro caspofungin activity.