Therapeutic efficacy of poly(DL-lactide-co-glycolide)-encapsulated antitubercular drugs against Mycobacterium tuberculosis infection induced in mice

Authors
Dutt, M Khuller, GK
Citation
M. Dutt et Gk. Khuller, Therapeutic efficacy of poly(DL-lactide-co-glycolide)-encapsulated antitubercular drugs against Mycobacterium tuberculosis infection induced in mice, ANTIM AG CH, 45(1), 2001, pp. 363-366
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
1
Year of publication
2001
Pages
363 - 366
Database
ISI
SICI code
0066-4804(200101)45:1<363:TEOPA>2.0.ZU;2-B
Abstract
Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carrie rs for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and inject ed in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in various organs of mice. Further, Mycobacterium tubercul osis H(37)Rv-infected animals given a single shot of chemotherapy in PLG mi croparticles exhibited a better or equivalent clearance of CFU in various o rgans compared to those given a daily administration of free drugs.