Modulation of NAD(P)H : quinone oxidoreductase (NQO1) activity mediated by5-arylamino-2-methyl-4,7-dioxobenzothiazoles and their cytotoxic potential

Authors
Ryu, CK Jeong, HJ Lee, SK Kang, HY Ko, KM Sun, YJ Song, EH Hur, YH Lee, CO
Citation
Ck. Ryu et al., Modulation of NAD(P)H : quinone oxidoreductase (NQO1) activity mediated by5-arylamino-2-methyl-4,7-dioxobenzothiazoles and their cytotoxic potential, ARCH PH RES, 23(6), 2000, pp. 554-558
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
23
Issue
6
Year of publication
2000
Pages
554 - 558
Database
ISI
SICI code
0253-6269(200012)23:6<554:MON:QO>2.0.ZU;2-Y
Abstract
Synthesized 5-arylamino-2-methyl-4,7-dioxobenzothiazoles 3a-3o were evaluat ed for modulation of NAD(P)H: quinone oxidoreductase (NQO1) activity with t he cytosolic fractions derived from cultured human lung cancer cells and th eir cytotoxicity in cultured several human solid cancer cell lines. The 4,7 -dioxobenzothiazoles affected the reduction potential by NQO1 activity and showed a potent cytotoxic activity against human cancer cell lines. The tes ted compounds 3a, 3b, 3g, 3h, 3n and 3o were considered as more potent cyto toxic agents, and comparable modulators of NQO1 activity.