Electrolyzed water accelerated the healing of full-thickness cutaneous woun
ds in rats, but only anode chamber water (acid pH or neutralized) was effec
tive. Hypochlorous acid (HOCl), also produced by electrolysis, was ineffect
ive, suggesting that these types of electrolyzed water enhance wound healin
g by a mechanism unrelated to the well-known antibacterial action of HOCl.
One possibility is that reactive oxygen species, shown to be electron spin
resonance spectra present in anode chamber water, might trigger early wound
healing through fibroblast migration and proliferation.