Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle

Authors
Li, Y Shan, F Wu, JM Wu, GS Ding, J Xiao, D Yang, WY Atassi, G Leonce, S Caignard, DH Renard, P
Citation
Y. Li et al., Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle, BIOORG MED, 11(1), 2001, pp. 5-8
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
5 - 8
Database
ISI
SICI code
0960-894X(20010108)11:1<5:NAADTG>2.0.ZU;2-T
Abstract
Modification of artemisinin structure led us to the discovery of a novel cl ass of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro against P38 8 and A549 cells. This activity was reflected in P388 murine leukemia by an accumulation of cells in G1 phase, and induction of apoptosis. (C) 2000 El sevier Science Ltd. All rights reserved.