[Lys(3)]didemnins as potential affinity ligands

Authors
Vera, MD Pfizenmayer, AJ Ding, XB Xiao, D Joullie, MM
Citation
Md. Vera et al., [Lys(3)]didemnins as potential affinity ligands, BIOORG MED, 11(1), 2001, pp. 13-16
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
13 - 16
Database
ISI
SICI code
0960-894X(20010108)11:1<13:[APAL>2.0.ZU;2-6
Abstract
The synthesis and biological activity of N-epsilon-Z-[Lys(3)]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and pr otein biosynthesis inhibition activities, but at reduced levels. This resul t suggests the use of [Lys(3)]didemnin derivatives as potential affinity pr obes for studying the molecular target(s) of the didemnin class of natural products. (C) 2000 Elsevier Science Ltd. All rights reserved.