Citation
M. Raoul et al., Synthesis of a novel series of cytotoxic bisindole alkaloids, BIOORG MED, 11(1), 2001, pp. 79-81
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
79 - 81
Database
ISI
SICI code
0960-894X(20010108)11:1<79:SOANSO>2.0.ZU;2-A
Abstract
Original cytotoxic bisindole alkaloids with a 1,2,3,4-tetrahydroquinoline b
ridge were synthesized by reductive amination with various anilines. The mo
st cytotoxic compounds display a high and dose-dependent cell cycle effect
with accumulation in the G1 phase. Influence of substitution of the startin
g aniline on the reaction and on cytotoxicity of produced dimers was pointe
d out. (C) 2000 Elsevier Science Ltd. All rights reserved.