Polymethylene derivatives of pyrimidine nucleic bases bearing omega-functional groups

Authors
Makinsky, AA Kritzyn, AM Uljanova, EA Zakharova, OD Nevinsky, GA
Citation
Aa. Makinsky et al., Polymethylene derivatives of pyrimidine nucleic bases bearing omega-functional groups, BIOORG KHIM, 26(10), 2000, pp. 735-742
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANICHESKAYA KHIMIYA
ISSN journal
01323423 → ACNP
Volume
26
Issue
10
Year of publication
2000
Pages
735 - 742
Database
ISI
SICI code
0132-3423(200010)26:10<735:PDOPNB>2.0.ZU;2-E
Abstract
N-1-Acyclic derivatives of pyrimidine bases (uracil, thymine, and cytosine) with hydrophobic polymethylene chains containing various functional groups in an omega -position of the alkyl substituent were synthesized. Their phy sicochemical properties and inhibitory effect on the HIV reverse transcript ase and human DNA topoisomerase I were studied.