Common chromosome aberrations in the proximal type of epithelioid sarcoma

A new case of the proximal type of epithelioid sarcoma with a complex karyo type 70-98 <4N>,XX, -X, -X,+5,i(5)(q10), +7,del(7)(q31),i(8)(q10)x3 similar to4,del(12)(p13) der(18)ins(18;?) (q11;?)del(18)(p11). ish der(18)ins(18;X )del(18)(p11)(wcp18+,wcpX+),+20,+20,dmin [cp9] is described. Both, dual-col or FISH using probes specific for OATLI1/OATL2 genes and RT-PCR analysis ex cluded the presence of t(X;18), typical for synovial sarcoma. Our case toge ther with the previously published ones suggest that the presence of i(8)(q 10), losses of 12p and 18p together with the gain of chromosome 20 may repr esent a common cytogenetic aberrations in the proximal type of epithelioid sarcoma. (C) 2000 Elsevier Science Inc. An rights reserved.