Typical CBF beta/MYH11 fusion due to insertion of the 3 '-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22

Authors
Aventin, A La Starza, R Nomdedeu, J Brunet, S Sierra, J Mecucci, C
Citation
A. Aventin et al., Typical CBF beta/MYH11 fusion due to insertion of the 3 '-MYH11 gene into 16q22 in acute monocytic leukemia with normal chromosomes 16 and trisomies 8 and 22, CANC GENET, 123(2), 2000, pp. 137-139
Citations number
10
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
123
Issue
2
Year of publication
2000
Pages
137 - 139
Database
ISI
SICI code
0165-4608(200012)123:2<137:TCBFDT>2.0.ZU;2-W
Abstract
In a case of acute monocytic leukemia, M5a according to the FAB classificat ion, with a 48,XY,+8,+22 karyotype, amplification of the CBF beta /MYH11 fu sion transcript type A was detected by reverse transcriptase-polymerase cha in reaction (RT-PCR). Fluorescence in situ hybridization (FISH) using an ap propriate panel of DNA probes showed that insertion of the 3'-MYH11 within the CBF beta gene on chromosome 16q22 was the mechanism producing the same molecular rearrangement as in typical inv(16)(p13q22)/t(16;16)(p13;q22). (C ) 2000 Elsevier Science Inc. All rights reserved.