Ya. Yeh et al., Trisomy 1q, 2, and 20 in a case of hepatoblastoma: Possible significance of 2q35-q37 and 1q12-q21 rearrangements, CANC GENET, 123(2), 2000, pp. 140-143
Combined cytogenetic, chromosome painting, and spectral karyotyping (SKY) a
nalyses in a cast of hepatoblastoma revealed a karyotype of 49,XY,+Y,+der(2
)t(2;3)(q35;q25),der(3)t( q25),+20. Trisomy 1q, 2, and 20 identified in the
present case are consistent with the previously reported cytogenetic alter
ations in hepatoblastoma. The breakpoints at 1q12 and 2q35 identified ill t
his case have also been reported previously as nonrandom changes. The frequ
ent occurrence of these rearrangements in hepatoblastoma suggests that they
may be of pathogenic significance, (C) 2000 Elsevier Science Inc. All righ
ts reserved.