Trisomy 1q, 2, and 20 in a case of hepatoblastoma: Possible significance of 2q35-q37 and 1q12-q21 rearrangements

Authors
Yeh, YA Rao, PH Cigna, CT Middlesworth, W Lefkowitch, JH Murty, VVVS
Citation
Ya. Yeh et al., Trisomy 1q, 2, and 20 in a case of hepatoblastoma: Possible significance of 2q35-q37 and 1q12-q21 rearrangements, CANC GENET, 123(2), 2000, pp. 140-143
Citations number
18
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
123
Issue
2
Year of publication
2000
Pages
140 - 143
Database
ISI
SICI code
0165-4608(200012)123:2<140:T12A2I>2.0.ZU;2-Q
Abstract
Combined cytogenetic, chromosome painting, and spectral karyotyping (SKY) a nalyses in a cast of hepatoblastoma revealed a karyotype of 49,XY,+Y,+der(2 )t(2;3)(q35;q25),der(3)t( q25),+20. Trisomy 1q, 2, and 20 identified in the present case are consistent with the previously reported cytogenetic alter ations in hepatoblastoma. The breakpoints at 1q12 and 2q35 identified ill t his case have also been reported previously as nonrandom changes. The frequ ent occurrence of these rearrangements in hepatoblastoma suggests that they may be of pathogenic significance, (C) 2000 Elsevier Science Inc. All righ ts reserved.