Simultaneous PML/RAR alpha and AML1/ETO expression with t(15;17) at onset and relapse with only t(8;21) in an acute promyelocytic leukemia patient

Authors
Bonomi, R Giordano, H Moreno, MD Bodega, E Landoni, AI Gallagher, R Uriarte, MD
Citation
R. Bonomi et al., Simultaneous PML/RAR alpha and AML1/ETO expression with t(15;17) at onset and relapse with only t(8;21) in an acute promyelocytic leukemia patient, CANC GENET, 123(1), 2000, pp. 41-43
Citations number
19
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
123
Issue
1
Year of publication
2000
Pages
41 - 43
Database
ISI
SICI code
0165-4608(200011)123:1<41:SPAAAE>2.0.ZU;2-2
Abstract
We report a patient with acute promyelocytic leukemia with the common trans location (15;17) and PML-RARA alpha fusion gene. In relapse, blasts showed typical FAB M2 morphologic features, and the karyotype was 45,X, -Y,t(8;21) . A reexamination of the leukemic cells at diagnosis revealed that an AML1- ETO fusion gene was also present at that time without cytogenetic evidence of t(8;21). In relapse, only t(8;21) was detected. Two different clones wer e identified by cytogenetic standard techniques. The association of two com mon translocations supervening in the same time in the same cells could not be established. (C) 2000 Elsevier Science Inc. All rights reserved.