I. Muszalska et al., Simultaneous determination of paracetamol, caffeine, ascorbic acid and phenylephrine hydrochloride in pharmaceutical formulations by HPLC, CHEM ANAL, 45(6), 2000, pp. 825-833
High performance liquid chromatography (HPLC) using LiChrospher 100 RP-18 (
250 x 4 mm, 5 mum) column as stationary phase was applied to determination
of paracetamol, caffeine, ascorbic acid and phenylephrine hydrochloride in
pharmaceutical preparations. The chromatographic system and stability of an
alite were selected. The relantioship between drug concentrations and peaks
heights, the accuracy, repeatability precision and linearity were tested u
sing the reference model mixtures.