Simultaneous determination of paracetamol, caffeine, ascorbic acid and phenylephrine hydrochloride in pharmaceutical formulations by HPLC

Authors
Muszalska, I Zajac, M Czajkowski, K Nogowska, M
Citation
I. Muszalska et al., Simultaneous determination of paracetamol, caffeine, ascorbic acid and phenylephrine hydrochloride in pharmaceutical formulations by HPLC, CHEM ANAL, 45(6), 2000, pp. 825-833
Citations number
14
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
CHEMIA ANALITYCZNA
ISSN journal
00092223 → ACNP
Volume
45
Issue
6
Year of publication
2000
Pages
825 - 833
Database
ISI
SICI code
0009-2223(2000)45:6<825:SDOPCA>2.0.ZU;2-S
Abstract
High performance liquid chromatography (HPLC) using LiChrospher 100 RP-18 ( 250 x 4 mm, 5 mum) column as stationary phase was applied to determination of paracetamol, caffeine, ascorbic acid and phenylephrine hydrochloride in pharmaceutical preparations. The chromatographic system and stability of an alite were selected. The relantioship between drug concentrations and peaks heights, the accuracy, repeatability precision and linearity were tested u sing the reference model mixtures.