To assess a possible association between antiretroviral treatment and paron
ychia, we conducted a retrospective cohort study of 288 human immunodeficie
ncy virus-positive protease inhibitor recipients. Indinavir treatment-adjus
ted for age, sex, CD4 count, diabetes status and other antiretroviral drug
exposures-was significantly associated with paronychia of the great toe (ha
zard ratio 4.7; 95% confidence interval 1.6-13.9).