Endotoxin, cytokines, and procalcitonin in febrile patients admitted to the hospital: Identification of subjects at high risk of mortality

We prospectively examined 464 febrile patients (median age, 61 years) for p redictors of in-hospital death, by use of univariate and multivariate logis tic regression using clinical data (age, underlying disease, duration of fe ver, chills, and shock on admission) and plasma endotoxin, TNF-alpha, IL-6, IL-10, and procalcitonin levels. The mortality rate was 4.6-fold higher (9 5% confidence interval [CI], 1.8-12) in 31 patients with shock on admission , 7 of whom died; the strongest association with mortality was the endotoxi n concentration (relative risk, 13.7; 95% CI, 1.4-136), which predicted 5 o f the deaths with a 5% false-positive rate. For 433 patients without shock on admission, mortality (26 deaths) was associated with age and underlying disease: clinical data predicted 30% of the deaths, whereas IL-6 and procal citonin levels identified an extra 10% with a 5% false- positive rate. When febrile patients are screened on hospital admission to identify those with a high risk for mortality, clinical judgment on the basis of age, underlyi ng disease, and recent history outweighs the predictive value of endotoxin, cytokine, and procalcitonin levels. Only in patients who present with shoc k will measurement of endotoxin levels help predict those who will likely d ie at the cost of few false- positive results.