This study was designed to investigate birth defects found in association w
ith newborn encephalopathy. All possible birth defects were ascertained in
a population-based study of 276 term infants with moderate or severe enceph
alopathy and 564 unmatched term control infants. A strong association betwe
en birth defects and newborn encephalopathy was found with defects affectin
g 27.5% of children with encephalopathy and 4.3% of control children (odds
ratio 8.55; 95% confidence interval 5.25 to 13.91; p<0.001). In 11.8% of in
fants with a birth defect the defect was not diagnosed until after the newb
orn period, illustrating one of the difficulties in attempting to exclude i
nfants with birth defects from studies of newborn encephalopathy. The major
ity of defects (89%) were not specific anomalies of the CNS. In 36.8% of ch
ildren with encephalopathy who had a birth defect, the defect was considere
d to be the probable cause of the encephalopathy. Infants with birth defect
s who had encephalopathy had a poorer prognosis than those without: they we
re twice as likely to die by the age of 2 years and three times more likely
to have cerebral palsy. This study catalogues the spectrum of birth defect
s associated with newborn encephalopathy and illustrates the importance of
their inclusion when investigating both the aetiology and outcome of this c
ondition.