Djm. Spalding et al., Combining high-throughput pharmacokinetic screens at the hits-to-leads stage of drug discovery, DRUG DISC T, 5(12), 2000, pp. S70-S76
Profound technological advances in the drug discovery process have led to t
he identification of an increasingly large number of promising compounds at
the hits-to-leads stage. Higher-throughput pharmacokinetic screens have th
erefore been developed to enhance the tractability of selected leads and mi
nimize the risk of failure in the later stages of drug development.