Studies have suggested that offspring of women hospitalized for hyperemesis
gravidarum have a different sex ratio than those of women without this dia
gnosis, but little is known of the potential association between fetal gend
er and variables such as severity of hyperemesis, gestational trimester, an
d maternal age. Our findings provide evidence that pregnant women with a di
agnosis of hyperemesis gravidarum in the first trimester give birth to a hi
gher proportion of female newborns than do all mothers, regardless of wheth
er they are hospitalized.