Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease

Background: Prevention of coronary heart disease (CHD) in high-risk subject s. Objective: To investigate the associations of dietary intake of alpha-linol enic acid (ALA) and linoleic acid (LA) as assessed by food frequency questi onnaire and in the plasma cholesteryl ester (CE), with CHD risk factors. Design: Baseline data of a double-blind, randomized placebo-controlled tria l. Subjects have hypercholesterolemia (6.0-8.0 mmol/l) and at least two oth er CHD risk factors (n = 266). Results: The reported dietary ALA and LA intakes and the LA/ALA ratio were associated with the contents in the CE (r = 0.37, r = 0.21, and r = 0.42, r espectively; P < 0.01). In multivariate analysis, CE ALA was inversely asso ciated with diastolic blood pressure (r = - 0.13; P < 0.05) and positively with serum triacylglycerol (r = 0.13; P < 0.05), and CE LA was inversely as sociated with serum triacylglycerol (r = - 0.32; P < 0.01). The CE LA/ALA r atio was strongly inversely associated with CE ALA (r = - 0.95; P < 0.01). In the lowest quintile of CE ALA, mean dietary intake was 0.4 energy % ALA (1.2 g/day), 8.4 energy % LA and an LA/ALA ratio of 21, and in the highest quintile 0.6 energy % ALA (1.7 g/day), 6.8 energy % LA and 12 (ratio). In t he lowest quintile of CE ALA the diastolic blood pressure was 4 mmHg lower (P trend < 0.05), and the serum triacylglycerol 0.3 mmol/l higher (P trend NS) when compared with the top quintile. Conclusions: In a CHD high-risk population with LA-rich background diet, th ese cross-sectional data suggest that replacing LA in the diet by ALA may d ecrease diastolic blood pressure, and may increase serum triacylglycerol co ncentration.