The spleen is generally not considered a challenge to the radiologist. Most
often it poses a problem by anomalies or an irregular but normal contrast
enhancement; however, a variety of inflammatory, infectious and neoplastic
diseases may involve the spleen. CT and ultrasonography are screening modal
ities for the spleen. For problem solving, MR imaging can be helpful, espec
ially due to its free choice of the imaging plane and because of the high r
esolution in contrast MR imaging. Splenic angiography as a diagnostic tool
has generally been replaced by CT, ultrasound, or MR and is now used as an
interventional method, e. g., in non-surgical management of patients with c
hronic idiopathic thrombocytopenia or in patients with splenic trauma. This
article reviews the radiology of the spleen, including anatomy, embryology
, splenomegaly, splenic injury, infarction, cysts, tumors,. abscesses, sarc
oidosis, and AIDS. Knowledge about the use of different imaging modalities
and underlying gross and microscopic pathologic features reads to a better
understanding of the radiologic findings.