HIV-1 tat protein induces interleukin-10 production by human peripheral blood monocytes

Citation
Y. Bennasser et al., HIV-1 tat protein induces interleukin-10 production by human peripheral blood monocytes, FIFTH EUROPEAN CONFERENCE ON EXPERIMENTAL AIDS RESEARCH (ECEAR 2000), 2000, pp. 11-17
Citations number
11
Categorie Soggetti
Current Book Contents
Year of publication
2000
Pages
11 - 17
Database
ISI
SICI code
Abstract
In HIV-infected patients, production of IL-IO, a highly immunosuppressive c ytokine, is associated with the progression of the disease towards AIDS. HI V-1 Tat, a protein secreted by infected cells and found free in the plasma of HIV-infected patients where it can interact with both infected and non-i nfected cells, could participate in this immune system disorder. In the present work, we show that Tat induces IL-IO production by periphera l blood monocytes of healthy donors in a dose and stimulation time-dependen t manner. We show that the protein kinase C pathway plays an essential role in IL-10 production and exogenous Tat activates a potential substrate of P KC the trancriptionnal factor NFkB, that is required for IL-10 prodution,. Finally our results suggest that the effects of Tat are exerted at the memb rane level.