A weighted test using both extreme discordant and concordant sib pairs fordetecting linkage

Citation
Zh. Li et Jl. Gastwirth, A weighted test using both extreme discordant and concordant sib pairs fordetecting linkage, GENET EPID, 20(1), 2001, pp. 34-43
Citations number
18
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETIC EPIDEMIOLOGY
ISSN journal
07410395 → ACNP
Volume
20
Issue
1
Year of publication
2001
Pages
34 - 43
Database
ISI
SICI code
0741-0395(200101)20:1<34:AWTUBE>2.0.ZU;2-2
Abstract
Statistical procedures using extremely discordant and concordant sib-pairs have been developed for mapping quantitative trail loci in humans. To impro ve the power of the existing methods, test statistics placing greater weigh t on the more discordant or more concordant pairs are proposed. Because the optimum choice of weights would depend on the underlying genetic model, wh ich is not usually known, a test with simple weights is suggested. This tes t is shown to have greater power than the currently available ones for a va riety of genetic models. Genet. Epidemiol. 20:34-43, 2001. (C) 2001 Wiley-L iss, Inc.