The abandoned radical hysterectomy: A Gynecologic Oncology Group Study

Objective. The aim of this study was to evaluate the frequency with which i ntended radical hysterectomy for cervical cancer is abandoned and the outco mes for those patients. Methods. A secondary evaluation of a prospective surgical pathological tria l was performed. There were 1127 patients with Stage TB carcinoma of the ce rvix entered on Gynecologic Oncology Group Protocol No. 49. These patients were to undergo radical hysterectomy and pelvic lymphadenectomy with carefu l analysis of pathologic findings, complications, and outcomes. Results. Ninety-eight women were found, at operation, to have extrauterine disease and the proposed radical operation was abandoned at the discretion of the operating surgeon. The records of these patients were evaluated. Sub groups of patients with extrapelvic disease (30) and pelvic extension (26), including grossly positive pelvic nodes (12), other pelvic implants (8), a nd gross serosal extension (2), were identified. Sixty-three (93%) patients subsequently underwent pelvic radiation therapy and one or two intracavita ry applications. Para-aortic fields were added for 8 patients who were foun d to have positive para-aortic nodes. Five patients received radiotherapy a nd chemotherapy; 4 patients received chemotherapy alone. One patient declin ed any further therapy. The disease-free survival was shorter for patients whose radical procedure was abandoned than for those patients who underwent radical hysterectomy. Among the abandoned-operation patients, those with e xtrapelvic disease had the shortest progression-free interval and survival and those with direct pelvic extension the longest. Conclusions. Retrospective comparisons of radical hysterectomy to radiation therapy are not valid unless the group of patients whose radical operation was abandoned is included. The morbidity of the operation is low even when followed by radiation therapy. However, no recommendations for optimal the rapy can be made from this analysis. (C) 2000 Academic Press.