The Medical Research Council trials in adult acute lymphocytic leukemia

Authors
Durrant, IJ Richards, SM Prentice, HG Goldstone, AH
Citation
Ij. Durrant et al., The Medical Research Council trials in adult acute lymphocytic leukemia, HEMAT ONCOL, 14(6), 2000, pp. 1327
Citations number
30
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
ISSN journal
08898588 → ACNP
Volume
14
Issue
6
Year of publication
2000
Database
ISI
SICI code
0889-8588(200012)14:6<1327:TMRCTI>2.0.ZU;2-Z
Abstract
This articles summarizes the history of Medical Research Council (MRC) acut e lymphocytic leukemia (ALL) trials in adults. It includes details of the e arly trials UKALL I-V in which children and adults were entered. UKALL IX, XA, and XII are for those older than 15 years of age (UKALL XII has an uppe r age limit of 55 years). The trials are all randomized controlled trials. The treatment schedules and survival curves are shown and discussed. A tota l of 2565 adults were entered between 1970 and 2000, and outcomes for all o f these patients are described.