Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ :: TnphoA mutant 30-5-1(3)

Authors
DeVinney, R Nisan, I Ruschkowski, S Rosenshine, I Finlay, BB
Citation
R. Devinney et al., Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ :: TnphoA mutant 30-5-1(3), INFEC IMMUN, 69(1), 2001, pp. 559-563
Citations number
24
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
1
Year of publication
2001
Pages
559 - 563
Database
ISI
SICI code
0019-9567(200101)69:1<559:TTPAPF>2.0.ZU;2-7
Abstract
Enteropathogenic Escherichia call (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphor ylation. In this study, we show that 30-5-1(3), which has a transposon inse rtion within the sepZ gene, forms wild-type A/E lesions including Tir tyros ine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3 ) occurs without detectable secretion of Tir or other EPEC Esp secreted pro teins.